Thermoresponsive polymer membrane for the local delivery of drugs

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Thermoresponsive polymer membrane for the local delivery of drugs

1Faculty of Pharmacy, University of Toronto; 2Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario Correspondence and reprints: Dr BA Saville, Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5. Telephone 416-978-7745, fax 416-978-8605, e-mail [email protected] CC N...

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Thermoresponsive nanogels for prolonged duration local anesthesia.

Nanogels based on poly(N-isopropylacrylamide) are attractive vehicles for prolonged duration local anesthesia because of their tunable size, number of functional groups, thermoresponsiveness and anionic charge. Nerve block durations of up to 9h were achieved using acrylic acid-loaded nanogels loaded with bupivacaine. Increasing the anionic charge density of the nanogels or (for more highly acid...

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ژورنال

عنوان ژورنال: Journal of Sexual & Reproductive Medicine

سال: 2001

ISSN: 1488-5069

DOI: 10.4172/1488-5069.1000005